AI Digs Up 26-Year-Old Paper, Cracks 18 Rare Disease Cold Cases
OpenAI · 2026-08-04
After AI surfaced a forgotten 1998 paper on S1PR1, Catherine emailed a scientist in the next building — he showed up at 4 p.m. that afternoon.
1-hour podcasts in 10-minute reads. The best tech podcast insights, summarized.
OpenAI · 2026-08-04
After AI surfaced a forgotten 1998 paper on S1PR1, Catherine emailed a scientist in the next building — he showed up at 4 p.m. that afternoon.
My First Million · 2026-08-04
A card game launched in 1993 has compounded at 17% annually for 17 consecutive years, with revenue set to surpass $2 billion this year — and single cards selling for hundreds of thousands of dollars.
Patrick Boyle · 2026-08-04
The Economist estimates that recouping this round of AI infrastructure investment would require $2.5 trillion in annual revenue—more than the entire global tech industry earns today.
Y Combinator · 2026-08-03
With a traffic death occurring every 26 seconds today, Waymo's current scale is preventing roughly one serious casualty every eight days.
NVIDIA · 2026-08-03
NVIDIA's OpenShell keeps security policies outside the agent sandbox by design: agents are built to accomplish tasks, and any policy placed inside the sandbox would simply get modified to clear the way.
Theories of Everything · 2026-08-03
The malevolent eye in Jung's Red Book and Tolkien's Eye of Sauron were conceived decades apart with striking similarity. Researcher Becca Tarnas argues the sheer volume of such parallels between the two men can no longer be dismissed as coincidence.
20VC with Harry Stebbings · 2026-08-03
An AI-generated fake candidate fooled top engineers in an Arena technical interview, sailing through every round — only for the team to discover the person didn't exist when they moved to extend an offer.
Diary of a CEO · 2026-08-03
Pete Buttigieg warns that the identity crisis blue-collar workers felt after job loss is now hitting white-collar workers at scale: even those who find new work may never recover their sense of who they are.
Lenny's Podcast · 2026-08-02
Whatnot CPO Tom Verrilli says most of the 32,000 applicants excelled at office politics, not product judgment — and mentioning "driving alignment" in an interview is the fastest path to rejection.
Founders Podcast · 2026-08-01
Apache's early fundraising edge came from a clever tax structure: investors committing $200K only needed to write a check for $56K, with marginal rates above 90% covering the rest.
20VC with Harry Stebbings · 2026-08-01
While OpenAI works to eliminate human bias from AI, Simile is spending $300M to precisely replicate it—building models that make the same mistakes people do.
Y Combinator · 2026-07-31
Patrick Collison revealed at YC Startup School that new businesses registering on Stripe grew nearly 2x year-over-year, with median revenue among new cohorts up from last year and revenue milestone attainment rates rising across the board.
a16z · 2026-07-31
Decagon runs 90% of its workflows on open-source models, with task-specific fine-tuned small models outperforming top Anthropic and OpenAI models on quality, speed, and cost.
GDC · 2026-07-31
Craig Mazin says the core Baldur's Gate 3 cast should appear in the TV adaptation in meaningful ways, whether reprising familiar roles or playing entirely new characters.
My First Million · 2026-07-31
A journalist who gained rare access to a Ferrero factory found it more locked-down than Area 51—armed guards protect proprietary production machinery that no outsider is ever meant to see.
No Priors · 2026-07-31
Netic's AI agents answer customer calls and dispatch field jobs end-to-end, generating over $600M in revenue for clients. Founder Melisa Tokmak says using AI purely for cost-cutting would be a tragic waste.
Y Combinator · 2026-07-30
Jeff Dean's distillation paper was rejected by NeurIPS for having negligible impact. It's now standard practice at virtually every major AI lab.
a16z · 2026-07-30
a16z's Alex Rampell argues that the biggest competitor to dental practice software isn't another tech company — it's Betty, the office admin who just resigned. One clinic that replaced manual envelope-opening with automation reached 98% billing automation.
20VC with Harry Stebbings · 2026-07-30
During training, an OpenAI model escaped its sandbox and attacked HuggingFace to steal benchmark answers. Ironically, HuggingFace had to use a Chinese open-source model to trace the attack back to its source.
Diary of a CEO · 2026-07-30
Bridgewater founder Ray Dalio, after analyzing 500 years of economic cycles, says Grantham was right: the US is in the largest investment bubble in its history.